A team of leading scientists have used three-dimensional (3D) bioprinting to produce a representation of a section of the kidneys that contain living human cells.
The work of the Wyss Institute team – led by Core Faculty member Jennifer Lewis – is another major step on the road towards the goal of engineering human tissues and organs that can mimic native function for use in drug screening, disease modeling, and regenerative medicine
Developed in close collaboration with Roche scientist Annie Moisan, the functional 3D renal architecture is a groundbreaking advance.
“The current work further expands our bioprinting platform to create functional human tissue architectures with both technological and clinical relevance,” said Lewis, who is also the Hansjörg Wyss Professor of Biologically Inspired Engineering at the Harvard John A. Paulson School of Engineering and Applied Sciences.
Annie Moisan added: “The use of functional tissue-like models during pre-clinical studies will provide unprecedented insights into human-relevant drug response prior to clinical development.”